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Understanding Recurrent Pregnancy Loss (RPL)
Recurrent pregnancy loss (RPL) is defined as two or more miscarriages
depending on age, and it affects about 1 in 100 couples trying to conceive. While miscarriage is common (occurring in 10-20% of known pregnancies), experiencing multiple losses can be heartbreaking and frustrating. The good news? Many causes of RPL can be identified and treated, improving your chances of a successful pregnancy.
Common Causes of Recurrent Pregnancy Loss
1. Genetic Factors
- Chromosomal abnormalities in the embryo cause up to 50% of early miscarriages.
- Parental genetic testing (karyotyping) can check for hidden issues in you or your partner.
- IVF with PGT-A testing helps select chromosomally normal embryos, reducing miscarriage risk.
2. Anatomic (Uterine) Issues
- Fibroids, polyps, or a misshapen uterus can interfere with implantation.
- Surgical correction (like hysteroscopy) often improves pregnancy success.
3. Hormonal & Metabolic Disorders
- Thyroid disease, uncontrolled diabetes, or PCOS can increase miscarriage risk.
- Hormonal insufficiency can be treated to improve the uterine lining.
4. Immunologic Causes
- Autoimmune conditions (like antiphospholipid syndrome) may cause blood clots in the placenta.
- Blood thinners (like heparin + aspirin) can improve outcomes.
5. Thrombophilias (Blood Clotting Disorders)
- Inherited clotting disorders (Factor V Leiden, MTHFR) may affect placental blood flow.
- Treatment with blood thinners can lower miscarriage risk.
6. Infections
- Chronic infections (like untreated STIs or uterine infections) may contribute to loss.
- Inflammation in the lining of the uterus can be tested and treated.
- Testing and antibiotics can help prevent future miscarriages.
7. Other Factors
- Lifestyle factors (smoking, extreme caffeine, toxins) may play a role.
- Other medical conditions and medications can be optimized prior to conception.
How Treatment Can Help
When a cause is found, targeted treatments (medication, surgery, or lifestyle changes) can significantly reduce miscarriage risk. For some, IVF with PGT-A testing offers the best chance by selecting genetically healthy embryos.
You Are Not Alone—We Can Help
If you’ve experienced multiple losses, testing can provide answers and a path forward. We specialize in finding and treating the causes of RPL, giving you the best chance for a healthy pregnancy, even if that means referral to additional expert care.
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